1799443-50-7 Fmoc-N-Me-D-Tyr(tBu)-OH

Fmoc-N-Me-D-Tyr(TBu)-OH, also known as N-α-(9-fluorenylmethoxycarbonyl)-N-α-methyl-D-tyrosine tert-butyl ester, is a protected amino acid derivative commonly used in solid-phase peptide synthesis. This compound combines the Fmoc protective group for the amino terminus with a tert-butyl (TBu) ester protecting the phenolic hydroxyl group of D-tyrosine.

The Fmoc group, as mentioned earlier, is stable and soluble in organic solvents, making it suitable for peptide synthesis. It can be removed easily under alkaline conditions, allowing for sequential assembly of peptides on solid supports. The tert-butyl ester, on the other hand, protects the phenolic hydroxyl group of D-tyrosine, ensuring its stability and purity during the synthesis process.

The primary application of Fmoc-N-Me-D-Tyr(TBu)-OH is in the preparation of peptides containing D-tyrosine. By using this amino acid derivative, researchers can introduce D-tyrosine with both the amino and phenolic hydroxyl groups protected into their peptide sequences. This offers precise control over the peptide structure and facilitates the introduction of other amino acids and modifications at specific positions within the peptide chain.

D-Tyrosine is a non-natural amino acid that can be incorporated into peptides to study their biological properties or to create peptide analogs with modified activities. Peptides containing D-tyrosine may have different biological activities compared to their L-tyrosine counterparts, due to the stereochemical differences between the two amino acids.